Macrophage heterogeneity in renal inflammation.

of bone marrow-derived cells to differentiate to glomerular mesangial cells. Extraglomerular origin of the mesangial cells after injury. marrow is a reservoir of repopulating mesangial cells during glomerular remodelling. A, Plati AR et al. Glomerulosclerosis is transmitted by bone marrow-derived mesangial cell progenitors. Bone marrow transplantation attenuates murine IgA nephropathy: role of a stem cell disorder. Blockade of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal inter-stitial fibrosis. A role for extrarenal cells in the regeneration following acute renal failure. Hodivala-Dilke K et al. Bone marrow contributes to renal parenchymal turnover and regeneration. Smad7 inhibits fibrotic effects of TGF-beta on renal tubular epithelial cells by blocking Smad2 activation.